1-PIPERAZINECARBOXYLIC ACID, 4-(3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 1-PIPERAZINECARBOXYLIC ACID, 4-(3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
• CAS No.: 223797-47-5
• Molecular Formula: C₁₄H₂₁N₃O₂
• Molecular Weight: 263.34
• Hs Code.: 2933990090
• Mol file: 223797-47-5.mol

Synonyms:1,1-Dimethylethyl4-(3-pyridinyl)-1-piperazinecarboxylate; 1-(3-Pyridyl)-4-(tert-butoxycarbonyl)piperazine;4-(Pyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl4-(pyridin-3-yl)piperazine-1-carboxylate

Chemical Property of 1-PIPERAZINECARBOXYLIC ACID, 4-(3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 42.43000
• LogP: 3.13400

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-(pyridin-3-yl)piperazine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PIPERAZINECARBOXYLIC ACID, 4-(3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER

There total 3 articles about 1-PIPERAZINECARBOXYLIC ACID, 4-(3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(pyridin-3-yl)piperazine (67980-77-2) → 1-(pyridin-3-yl)-4-tert-butoxycarbonylpiperazine (223797-47-5)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

DOI:10.1021/jm058058h

Reference yield: 70.0%

3-Bromopyridine (626-55-1,163928-56-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-(pyridin-3-yl)-4-tert-butoxycarbonylpiperazine (223797-47-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; at 110 ℃; for 16h; Sealed tube;

Reference yield:

→ 1-(pyridin-3-yl)-4-tert-butoxycarbonylpiperazine (223797-47-5)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120 ℃; Inert atmosphere;

upstream raw materials:

di-tert-butyl dicarbonate

1-(pyridin-3-yl)piperazine

3-Bromopyridine

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

1-(3-phenylpropyl)-4-(pyridin-3-yl)piperazine

1-(2-phenylethyl)-4-(3-pyridyl)piperazine

1-benzyl-4-(3'-pyridinyl)piperazine

1-(pyridin-3-yl)piperazine