(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Base Information

Chemical Name:(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide
CAS No.:923272-56-4
Molecular Formula:C₂₀H₂₀N₆O₅S
Molecular Weight:456.482
Hs Code.:

Synonyms:(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

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Chemical Property of (+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

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Technology Process of (+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

There total 3 articles about (+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 732276-92-5
(+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothiohydrazide

: 624-83-9
methyl isocyanate

: 923272-56-4
(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Guidance literature:: In chloroform; for 1h;

Reference yield:

: (+/-)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl chloride

: 923272-56-4
(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran / 1.5 h / 5 - 10 °C

2: chloroform / 1 h

With hydrazine; In tetrahydrofuran; chloroform;

Reference yield:

: 143692-49-3,161832-62-8,161832-63-9
1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine

: 923272-56-4
(+/-)-1-{8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbothioyl}-4-methyl-semicarbazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; triethylamine / toluene / 16 h / 20 - 30 °C

1.2: 7 h / 20 °C

2.1: hydrazine / tetrahydrofuran / 1.5 h / 5 - 10 °C

3.1: chloroform / 1 h

With chloro-trimethyl-silane; triethylamine; hydrazine; In tetrahydrofuran; chloroform; toluene;