methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

Base Information

Chemical Name:methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate
CAS No.:1616280-42-2
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:

Synonyms:methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

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Chemical Property of methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

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Technology Process of methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

There total 8 articles about methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1616280-40-0
methyl 3-{4-[2-(1-methyl-5-oxopyrrolidin-2-yl)-4-nitrophenoxy]phenyl}propanoate

: 1616280-42-2
methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; methanol; water; for 1h; Reflux;

Reference yield:

: 1314725-24-0
5-(2-chloro-5-nitrophenyl)pyrrolidin-2-one

: 1616280-42-2
methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate / ISOPROPYLAMIDE / 3 h / 120 °C

3.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 1 h / Reflux

With iron; sodium hydride; potassium carbonate; ammonium chloride; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 1616281-06-1
methyl 4-(2-chloro-5-nitrophenyl)-4-hydroxybutanoate

: 1616280-42-2
methyl 3-{4-[4-amino-2-(1-methyl-5-oxopyrrolidin-2-yl)phenoxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylazodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2.1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 90 °C

2.2: 16 h / 90 °C

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 1 h / 20 °C

4.1: potassium carbonate / ISOPROPYLAMIDE / 3 h / 120 °C

5.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 1 h / Reflux

With diphenyl phosphoryl azide; iron; sodium hydride; potassium carbonate; ammonium chloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;