ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

Base Information

Chemical Name:ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate
CAS No.:1080671-49-3
Molecular Formula:C₁₉H₂₆FN₂O₆P
Molecular Weight:428.397
Hs Code.:

Synonyms:ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

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Chemical Property of ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

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Technology Process of ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

There total 6 articles about ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.1%

: 1080671-47-1
ethyl 4-(3-bromopropyl)-3-((diethoxyphosphoryl)methyl)-5-(4-fluorophenyl)-4,5-dihydro-1,2,4-oxadiazole-5-carboxylate

: 1080671-49-3
ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -70 - 12 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm201407j

Reference yield:

: 1080671-48-2
C₁₉H₂₇FIN₂O₆P

: 1080671-49-3
ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

Guidance literature:: C₁₉H₂₇FIN₂O₆P; With potassium tert-butylate; In tetrahydrofuran; at -65 - -40 ℃;

With ammonium chloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 110841-50-4
N-<2-(diethoxyphosphoryl)ethylidene>hydroxylamine

: 1080671-49-3
ethyl 8-(diethoxyphosphoryl)-3-(4-fluorophenyl)-5,6,7,8-tetrahydro-3H-[1,2,4]oxadiazolo[4,3-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / -30 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / -10 - 20 °C

3: potassium tert-butylate / tetrahydrofuran / 2 h / -70 - 12 °C / Inert atmosphere

With N-Bromosuccinimide; potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201407j