5-(3-Fluorophenyl)furan-2-carbaldehyde

Base Information

• Chemical Name: 5-(3-Fluorophenyl)furan-2-carbaldehyde
• CAS No.: 33342-18-6
• Molecular Formula: C11H7 F O2
• Molecular Weight: 190.174
• DSSTox Substance ID: DTXSID60405456
• Mol file: 33342-18-6.mol

Synonyms:5-(3-fluorophenyl)furan-2-carbaldehyde;33342-18-6;5-(3-Fluoro-phenyl)-furan-2-carbaldehyde;SCHEMBL7328684;DTXSID60405456;5-(3-fluorophenyl)-2-furaldehyde;AKOS000297338;5-(3-fluorophenyl)-2-Furancarboxaldehyde;VS-08064;BB 0222871;CS-0263104;FT-0726824;EN300-8515936;Z385048860

Chemical Property of 5-(3-Fluorophenyl)furan-2-carbaldehyde

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 190.04300762
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

97% ^*data from raw suppliers

5-(3-fluorophenyl)furan-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)C2=CC=C(O2)C=O

Technology Process of 5-(3-Fluorophenyl)furan-2-carbaldehyde

There total 7 articles about 5-(3-Fluorophenyl)furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-formylfurane-2-boronic acid (27329-70-0) + 1-Fluoro-3-iodobenzene (1121-86-4) → 5-(3'-fluorophenyl)furan-2-carbaldehyde (33342-18-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 65 ℃; for 1h;

DOI:10.1016/j.ejmech.2016.12.024

Reference yield: 87.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + tris(3-flourophenyl)bismuthine (33756-24-0) → 5-(3'-fluorophenyl)furan-2-carbaldehyde (33342-18-6)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 1h;

DOI:10.1055/s-0032-1316567

Reference yield: 84.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 3-fluorophenylboronic acid (768-35-4) → 5-(3'-fluorophenyl)furan-2-carbaldehyde (33342-18-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b00618

upstream raw materials:

5-bromo-2-furancarboxaldehyde

3-fluorophenylboronic acid

furfural

meta-fluoroaniline

Downstream raw materials:

(E)-5-(3'-fluorophenyl)furan-2-carbaldehyde 4-bromobenzoylhydrazone

(Z)-5-((5-(3-fluorophenyl)furan-2-yl)methylene)-2-iminothiazolidin-4-one

[5-(3-fluoro-phenyl)-furan-2-yl]-methanol

C₁₉H₁₂F₃NO₄