4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI)

Base Information

• Chemical Name: 4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI)
• CAS No.: 223677-90-5
• Molecular Formula: C₁₀H₁₈O₂
• Molecular Weight: 170.252
• Mol file: 223677-90-5.mol

Synonyms:4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI)

Chemical Property of 4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI)

Chemical Property:

• PSA: 18.46000
• LogP: 2.04150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI)

There total 8 articles about 4H-Furo[2,3-b]pyran,hexahydro-3-(1-methylethyl)-,(3aR,7aS)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-3-iodo-2-(3-methyl-2-butenyloxy)tetrahydropyran (260557-53-7) → 7-isopropyl-1,6-cis-2,9-dioxabicyclo[4.3.0]nonane (223677-90-5,260557-60-6)

Guidance literature:

With phenylsilane; potassium carbonate; In(OAc)3; In tetrahydrofuran; at 70 ℃; for 24h;

DOI:10.1021/jo061880o

Reference yield: 92.0%

trans-3-bromo-2-(3-methyl-2-butenyloxy)tetrahydropyran (121693-22-9) → 7-isopropyl-1,6-cis-2,9-dioxabicyclo[4.3.0]nonane (223677-90-5,260557-60-6)

Guidance literature:

With zirconocene dichloride; triethyl borane; In tetrahydrofuran; hexane; at 25 ℃; for 3h;

DOI:10.1246/bcsj.77.1727

Reference yield: 88.0%

trans-3-bromo-2-(3-methyl-2-butenoxy)-1-oxacyclohexane → 7-isopropyl-1,6-cis-2,9-dioxabicyclo[4.3.0]nonane (223677-90-5,260557-60-6)

Guidance literature:

With hypophosphorous acid; α,α'-azodiizobutyramidine-dihydrochloride; sodium hydrogencarbonate; In ethanol; for 3h; Heating;

DOI:10.1246/bcsj.74.225

upstream raw materials:

trans-3-iodo-2-(3-methyl-2-butenyloxy)tetrahydropyran

trans-3-bromo-2-(3-methyl-2-butenyloxy)tetrahydropyran

3,4-dihydro-2H-pyran