4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate

Base Information

• Chemical Name: 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate
• CAS No.: 1276114-18-1
• Molecular Formula: C₆₂H₇₁NO₁₂Si
• Molecular Weight: 1050.33
• Mol file: 1276114-18-1.mol

Synonyms:4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate

Chemical Property of 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate

There total 12 articles about 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(phenylcarboxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate (1276114-17-0) → 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate (1276114-18-1)

Guidance literature:

With di(n-butyl)tin oxide; In methanol; at 120 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1039/c0cc04686h

Reference yield:

C69H74NO13PolSi → 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate (1276114-18-1)

Guidance literature:

With di(n-butyl)tin oxide; In methanol; dichloromethane; at 120 ℃; for 0.166667h; Microwave irradiation; solid phase reaction;

DOI:10.1039/c0cc04686h

Reference yield:

C47H50O8SSi (1276114-16-9) → 4-(hydroxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate (1276114-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 4 h / -20 - 20 °C / Molecular sieve; Inert atmosphere

2: di(n-butyl)tin oxide / methanol / 0.67 h / 120 °C / Microwave irradiation

With N-iodo-succinimide; trifluorormethanesulfonic acid; di(n-butyl)tin oxide; In methanol; dichloromethane;

DOI:10.1039/c0cc04686h

upstream raw materials:

4-(phenylcarboxymethyl)benzyl N-benzyl-N-(5-(3-O-benzyl-2-O-benzoyl-4-O-levulinoyl-6-O-tert-butyldiphenylsilyl-α-L-idopyranosyloxy)pentyl)carbamate

C₄₇H₅₀O₈SSi

N-benzyl-5-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)pentan-1-amine

4-(hydroxymethyl)benzyl 2,2,2-trichloroethylcarbonate

Refernces