4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

Base Information

Chemical Name:4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole
CAS No.:302839-18-5
Molecular Formula:C₁₅H₁₉Br₂FN₂OSi
Molecular Weight:450.221
Hs Code.:

Synonyms:4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

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Technology Process of 4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

There total 2 articles about 4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1765-93-1
4-fluoroboronic acid

: 159590-01-9
2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole

: 302839-18-5
4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 110 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation; Sealed tube;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 302839-18-5
4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1.5 h / 0 - 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 110 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;

Reference yield:

: 302839-18-5
4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

: 4-bromo-5-chloro-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

Guidance literature:: 4,5-dibromo-2-(4-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With hexachloroethane; In tetrahydrofuran; at -78 ℃; for 2h;