Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI)

Base Information

• Chemical Name: Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI)
• CAS No.: 223605-17-2
• Molecular Formula: C₁₀H₂₀N₂O
• Molecular Weight: 184.282
• Mol file: 223605-17-2.mol

Synonyms:Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI);CIS-4-PIPERAZIN-1-YLCYCLOHEXANOL

Chemical Property of Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI)

Chemical Property:

• PSA: 35.50000
• LogP: 0.46180

Purity/Quality:

97% ^*data from raw suppliers

cis-4-Piperazin-1-yl-cyclohexanol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI)

There total 3 articles about Cyclohexanol, 4-(1-piperazinyl)-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1s,4s)-4-(4-benzylpiperazin-1-yl)cyclohexanol → (1s,4s)-4-(piperazin-1-yl)cyclohexanol (223605-18-3,223605-17-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 16h;

Reference yield:

1-phenylmethylpiperazine (2759-28-6) + trans-4-(4-Benzylpiperazin-1-yl)cyclohexanol → trans-4-Piperazin-1-yl-cyclohexanol (223605-18-3,223605-17-2)

Guidance literature:

With sodium tetrahydroborate; hydrogen; In ethanol; palladium;

Reference yield:

cis-4-aminocyclohexanol (6850-65-3,27489-62-9,40525-78-8) → (1s,4s)-4-(piperazin-1-yl)cyclohexanol (223605-18-3,223605-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 6 h / 90 °C

2: palladium on activated charcoal; hydrogen / ethanol / 16 h / 20 °C

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In ethanol;

upstream raw materials:

1-phenylmethylpiperazine

cis-4-aminocyclohexanol

Downstream raw materials:

tert-butyl 4-((1r,4r)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

3-(4-phenoxyphenyl)-1-((1r,4r)-4-(piperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Refernces

• 1、 -. "HCK DEGRADERS AND USES THEREOF". . . Retrieved 2021/01/23.