Technology Process of (17E)-16α-allyl-3β,6β-dibenzyloxy-5α-pregn-17(20)-en-16β-ol
There total 11 articles about (17E)-16α-allyl-3β,6β-dibenzyloxy-5α-pregn-17(20)-en-16β-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
allylmagnesium bromide;
With
aluminum (III) chloride;
In
tetrahydrofuran; diethyl ether;
at -30 ℃;
for 0.166667h;
(17E)-3β,6β-dibenzyloxy-5α-pregn-17(20)-en-16-one;
In
tetrahydrofuran; diethyl ether;
at -30 ℃;
for 0.333333h;
DOI:10.1002/chem.201100503
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine; trichlorophosphate / 0 - 25 °C
2.1: boron trifluoride diethyl etherate; sodium cyanoborohydride / tetrahydrofuran / 2.58 h / 50 °C
3.1: methanol; sodium hydroxide / 4 h / 25 °C
4.1: sodium hydride / tetrahydrofuran; hexanes; N,N-dimethyl-formamide / 0.5 h / 25 °C
4.2: 48 h / 25 °C / light protection
5.1: tert.-butylhydroperoxide; selenium(IV) oxide / decane; dichloromethane / 4 h / 0 °C
6.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C
7.1: aluminum (III) chloride / tetrahydrofuran; diethyl ether / 0.17 h / -30 °C
7.2: 0.33 h / -30 °C
With
pyridine; methanol; tert.-butylhydroperoxide; selenium(IV) oxide; aluminum (III) chloride; boron trifluoride diethyl etherate; sodium hydride; sodium cyanoborohydride; Dess-Martin periodane; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; hexanes; diethyl ether; decane; dichloromethane; N,N-dimethyl-formamide;
4.1: Williamson synthesis / 4.2: Williamson synthesis;
DOI:10.1002/chem.201100503
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butylhydroperoxide; selenium(IV) oxide / decane; dichloromethane / 4 h / 0 °C
2.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C
3.1: aluminum (III) chloride / tetrahydrofuran; diethyl ether / 0.17 h / -30 °C
3.2: 0.33 h / -30 °C
With
tert.-butylhydroperoxide; selenium(IV) oxide; aluminum (III) chloride; Dess-Martin periodane;
In
tetrahydrofuran; diethyl ether; decane; dichloromethane;
DOI:10.1002/chem.201100503
