N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

Base Information

Chemical Name:N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide
CAS No.:1352792-37-0
Molecular Formula:C₁₈H₂₁N₅O₂S
Molecular Weight:371.463
Hs Code.:

Synonyms:N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

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Chemical Property of N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

Chemical Property:

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Technology Process of N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

There total 3 articles about N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5448-49-7
2-chloro-N-(1,3-thiazol-2-yl)acetamide

: 351343-88-9
4-(2-(piperazin-1-yl)ethoxy)benzonitrile

: 1352792-37-0
N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 8h; Cooling with ice;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 37142-39-5
4-(2-bromoethoxy)benzonitrile

: 1352792-37-0
N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

2: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

With hydrogen bromide; triethylamine; In ethanol; chloroform; water;
DOI:10.1016/j.ejmech.2014.03.075

Reference yield:

: 767-00-0
4-cyanophenol

: 1352792-37-0
N-(thiazol-2-yl)-2-(4-(2-(4-cyanophenoxy)ethyl)piperazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 24 h / 50 °C / Reflux

2: hydrogen bromide / water; ethanol / 48 h / 20 °C / Reflux

3: triethylamine / chloroform / 8 h / 20 °C / Cooling with ice

With hydrogen bromide; potassium carbonate; triethylamine; In ethanol; chloroform; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.03.075