tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate
CAS No.:1351168-22-3
Molecular Formula:C₂₁H₂₉FN₂O₇S
Molecular Weight:472.535
Hs Code.:

Synonyms:tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.5%

: 1351168-21-2
tert-butyl 4-((3S,4S)-4-(benzyloxy)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

: 1351168-22-3
tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield:

: 1351168-19-8
tert-butyl 4-((3R,4S)-4-(benzyloxy)-3-(methylsulfonyloxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

: 1351168-22-3
tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 70 °C / Inert atmosphere

2: trans-1,2-cyclohexanediamine; copper(I) triflate benzene complex / dimethyl sulfoxide / 110 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol

With hydrogen; potassium carbonate; copper(I) triflate benzene complex; palladium 10% on activated carbon; trans-1,2-cyclohexanediamine; In ethanol; dimethyl sulfoxide;

Reference yield:

: 1351168-20-1
tert-butyl 4-((3S,4S)-4-(benzyloxy)-3-(4-bromo-2-fluorophenoxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

: 1351168-22-3
tert-butyl 4-((3S,4S)-3-(2-fluoro-4-(methylsulfonyl)phenoxy)-4-hydroxy-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trans-1,2-cyclohexanediamine; copper(I) triflate benzene complex / dimethyl sulfoxide / 110 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol

With hydrogen; copper(I) triflate benzene complex; palladium 10% on activated carbon; trans-1,2-cyclohexanediamine; In ethanol; dimethyl sulfoxide;