1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Base Information

Chemical Name:1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide
CAS No.:1426397-20-7
Molecular Formula:C₂₃H₁₆FN₅O₅S
Molecular Weight:493.475
Hs Code.:

Synonyms:1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

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Chemical Property of 1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

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Technology Process of 1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

There total 5 articles about 1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₁ClFN₃O₃S

: 100-01-6,104810-17-5
4-nitro-aniline

: 1426397-20-7
1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm301643a

Reference yield:

: 658-27-5
m-fluorophenylhydrazine

: 1426397-20-7
1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / Reflux

2: sodium hydroxide / methanol / 1 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301643a

Reference yield:

: C₁₂H₁₁NO₆S

: 1426397-20-7
1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / Reflux

2: sodium hydroxide / methanol / 1 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301643a