(2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol

Base Information

• Chemical Name: (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol
• CAS No.: 1448529-92-7
• Molecular Formula: C₃₈H₆₉NO₈
• Molecular Weight: 667.968

Synonyms:(2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol

Chemical Property of (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol

There total 11 articles about (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2S,3S,4R)-1-O-(2',3',4',6'-tetra-O-benzyl-α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol (1448529-91-6) → (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol (1448529-92-7)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In methanol; dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2013.06.051

Reference yield:

(2R,3S,4R)-2-azidooctadecane-1,3,4-triol (201002-41-7) → (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol (1448529-92-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 2,6-dimethylpyridine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / water; tetrahydrofuran / 0 °C / Inert atmosphere

3: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane; diethyl ether / 2 h / 20 °C / Inert atmosphere; Molecular sieve

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 3 h / 0 - 20 °C / Inert atmosphere

6: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

7: sodium cyanoborohydride / methanol / 20 °C / Inert atmosphere

8: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; dichloromethane / 1 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; N-iodo-succinimide; nickel(II) chloride hexahydrate; trifluorormethanesulfonic acid; 20% palladium hydroxide-activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

DOI:10.1016/j.tet.2013.06.051

Reference yield:

(2S,3S,4R)-2-azido-1,3,4-tri-tert-butyldimethylsilyloxy-1,3,4-octadecanetriol (1256376-20-1) → (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol (1448529-92-7)

Guidance literature:

Multi-step reaction with 7 steps

1: trifluoroacetic acid / water; tetrahydrofuran / 0 °C / Inert atmosphere

2: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane; diethyl ether / 2 h / 20 °C / Inert atmosphere; Molecular sieve

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 3 h / 0 - 20 °C / Inert atmosphere

5: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

6: sodium cyanoborohydride / methanol / 20 °C / Inert atmosphere

7: hydrogen; 20% palladium hydroxide-activated charcoal / methanol; dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; N-iodo-succinimide; nickel(II) chloride hexahydrate; trifluorormethanesulfonic acid; 20% palladium hydroxide-activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

DOI:10.1016/j.tet.2013.06.051

upstream raw materials:

(2R,3S,4R)-2-azidooctadecane-1,3,4-triol

(2S,3S,4R)-2-azido-1,3,4-tri-tert-butyldimethylsilyloxy-1,3,4-octadecanetriol

p-methylphenyl 2,3,4,6-tetra-O-benzyl-1-thio-β-D-galactopyranoside

(2S,3S,4R)-2-amino-1-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)octadecane-1,3,4-triol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1448529-92-7 (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(8-phenyloctylamino)-1,3,4-octadecanetriol

Send

Send

Metric Ton KG G Pound L ML

Send

Send