2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid
• CAS No.: 550378-17-1
• Molecular Formula: C₂₅H₃₃Cl₂N₅O₅
• Molecular Weight: 554.474

Synonyms:2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid

Chemical Property of 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid

Chemical Property:

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Technology Process of 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid

There total 2 articles about 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid (25691-37-6,80445-78-9) + 4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl chloride (550378-12-6) → 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid (550378-17-1)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2004.12.045

Reference yield:

4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine → 2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid (550378-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / -78 - 20 °C

2: Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2004.12.045

Reference yield:

2-tert-butoxycarbonylamino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid (550378-17-1) → 2-amino-4-({4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl}-amino)-butyric acid

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2004.12.045

upstream raw materials:

(2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid

4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine-1-carbonyl chloride

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