ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

Base Information

Chemical Name:ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate
CAS No.:1363149-11-4
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

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Chemical Property of ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

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Technology Process of ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

There total 6 articles about ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 1363149-07-8
5-(4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl)-2-methyloxazole

: 1363149-11-4
ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

Guidance literature:: ethyl N-diphenylmethylene glycine; 5-(4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl)-2-methyloxazole; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In ethyl acetate; acetonitrile; at 80 ℃; Inert atmosphere;

With hydrogenchloride; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1363149-11-4
ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 47 h / 20 - 40 °C

2.1: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3.1: trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene / 0.5 h / 20 °C / Reflux

3.2: Reflux

4.1: sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 0 - 80 °C / Inert atmosphere

5.1: triethylamine / copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride / 3 h / 70 °C

6.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / ethyl acetate; acetonitrile / 80 °C / Inert atmosphere

6.2: 1 h / 20 °C

With trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 801303-33-3
4-bromo-2-fluoro-N-methoxy-N-methylbenzamide

: 1363149-11-4
ethyl 2-amino-7-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]hept-6-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

2.1: trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene / 0.5 h / 20 °C / Reflux

2.2: Reflux

3.1: sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 0 - 80 °C / Inert atmosphere

4.1: triethylamine / copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride / 3 h / 70 °C

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / ethyl acetate; acetonitrile / 80 °C / Inert atmosphere

5.2: 1 h / 20 °C

With trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;