7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Base Information

Chemical Name:7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride
CAS No.:1312448-55-7
Molecular Formula:C₂₂H₂₀FN₃O*ClH
Molecular Weight:397.88
Hs Code.:

Synonyms:7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Suppliers and Price of 7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

There total 5 articles about 7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312448-56-8
7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one

: 1312448-55-7
7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃;

Reference yield:

: 170491-63-1
N-Boc-prolinol

: 1312448-55-7
7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: potassium hydroxide / 1,4-dioxane / Reflux

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3.2: 20 °C / pH 8 - 9

4.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C

4.2: 20 °C

5.1: hydrogenchloride / diethyl ether / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;

Reference yield:

: 1092681-48-5
2-(S)-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic Acid Tert-butyl Ester

: 1312448-55-7
7-((3-fluorophenyl)ethynyl)-3-((1-methylpyrrolidin-2-yl)methyl)quinazolin-4(3H)-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / 1,4-dioxane / Reflux

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.2: 20 °C / pH 8 - 9

3.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C

3.2: 20 °C

4.1: hydrogenchloride / diethyl ether / 20 °C

With hydrogenchloride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; potassium hydroxide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;