6-(4-Fluorophenyl)-nicotinic acid

Base Information Edit

Chemical Name:6-(4-Fluorophenyl)-nicotinic acid
CAS No.:223127-24-0
Molecular Formula:C12H8 F N O2
Molecular Weight:217.199
Hs Code.:2933399990
Mol file:223127-24-0.mol

Synonyms:6-(4-Fluorophenyl)nicotinicacid; 6-(4-Fluorophenyl)pyridine-3-carboxylic acid

Suppliers and Price of 6-(4-Fluorophenyl)-nicotinic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
6-(4-Fluorophenyl)nicotinic acid
5 g
$ 1680.00

Matrix Scientific
6-(4-Fluorophenyl)nicotinic acid 97%
1g
$ 488.00

Crysdot
6-(4-Fluorophenyl)nicotinicacid 95+%
5g
$ 792.00

Crysdot
6-(4-Fluorophenyl)nicotinicacid 95+%
10g
$ 1188.00

Crysdot
6-(4-Fluorophenyl)nicotinicacid 95+%
25g
$ 2079.00

Chemenu
6-(4-Fluorophenyl)nicotinicacid 95%
25g
$ 1964.00

Chemenu
6-(4-Fluorophenyl)nicotinicacid 95%
10g
$ 1122.00

Chemenu
6-(4-Fluorophenyl)nicotinicacid 95%
5g
$ 748.00

Chemenu
6-(4-Fluorophenyl)nicotinicacid 95%
1g
$ 204.00

Atlantic Research Chemicals
6-(4-Fluorophenyl)nicotinicacid 95%
1gm:
$ 187.33

Total 10 raw suppliers

Chemical Property of 6-(4-Fluorophenyl)-nicotinic acid Edit

Chemical Property:

Boiling Point:384.5±32.0 °C(Predicted)
PKA:2.14±0.10(Predicted)
PSA：50.19000
Density:1.318±0.06 g/cm3(Predicted)
LogP:2.58590
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-(4-Fluorophenyl)nicotinic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-(4-Fluorophenyl)nicotinic acid is used as a reactant in the design and synthesis of substituted quinolines as novel and selective melanin-containing hormone receptor antagonists as anti-obesity agents.

Technology Process of 6-(4-Fluorophenyl)-nicotinic acid

There total 5 articles about 6-(4-Fluorophenyl)-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 149500-84-5
methyl 6-(4-fluorophenyl)nicotinate

: 223127-24-0
6-(4-fluorophenyl)-pyridine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 223127-24-0
6-(4-fluorophenyl)-pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus(V) oxybromide / toluene / 3 h / 90 °C

2: palladium diacetate; cesium fluoride / DMF (N,N-dimethyl-formamide); water / 17 h / 80 °C

3: sodium hydroxide; water / tetrahydrofuran / 15 h / 20 °C

With sodium hydroxide; water; phosphorus(V) oxybromide; palladium diacetate; cesium fluoride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; toluene;