(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

Base Information

Chemical Name:(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol
CAS No.:214342-03-7
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

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Chemical Property of (1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

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Technology Process of (1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

There total 8 articles about (1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100-46-9
benzylamine

: [(4S,5R)-2,2-Dimethyl-5-((2R,3S)-3-vinyl-oxiranyl)-[1,3]dioxolan-4-yl]-methanol

: 214342-03-7
(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In dimethyl sulfoxide; at 100 ℃;
DOI:10.1016/S0040-4039(98)01536-6

Reference yield:

: 132352-49-9
ethyl (E)-3-((4S,5S)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate

: 214342-03-7
(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / DIBAL / CH₂Cl₂ / -78 °C

2: 80 percent / (+)-DIPT, Ti(Oi-Pr)4, TBHP / CH₂Cl₂ / -20 °C

3: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 °C

4: 73 percent / KHMDS / tetrahydrofuran; toluene

5: 88 percent / DDQ / CH₂Cl₂; H₂O

6: 76 percent / p-toluenesulfonic acid / dimethylsulfoxide / 100 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; oxalyl dichloride; L-(+)-diisopropyl tartrate; potassium hexamethylsilazane; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(98)01536-6

Reference yield:

: 132352-47-7
(E)-3-((4S,5S)-5-((4-ethoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol

: 214342-03-7
(1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / (+)-DIPT, Ti(Oi-Pr)4, TBHP / CH₂Cl₂ / -20 °C

2: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 °C

3: 73 percent / KHMDS / tetrahydrofuran; toluene

4: 88 percent / DDQ / CH₂Cl₂; H₂O

5: 76 percent / p-toluenesulfonic acid / dimethylsulfoxide / 100 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; oxalyl dichloride; L-(+)-diisopropyl tartrate; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(98)01536-6