3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine

Base Information

• Chemical Name: 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine
• CAS No.: 865447-07-0
• Molecular Formula: C₃₂H₄₈IN₅O₄Si₂
• Molecular Weight: 749.84
• Mol file: 865447-07-0.mol

Synonyms:3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine

Chemical Property of 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine

There total 4 articles about 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-4-desmethylwyosine (865447-06-9) + 1-bromomethyl-4-iodobenzene (16004-15-2) → 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine (865447-07-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

DOI:10.1055/s-2005-869905

Reference yield:

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (51549-35-0) → 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine (865447-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylsulfoxide / 1 h / 20 °C

1.2: 85 percent / dimethylsulfoxide / 20 °C

2.1: 57 percent / K₂CO₃ / dimethylformamide / 2.5 h / 20 °C

With sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-869905

Reference yield:

2'-Deoxyguanosine (961-07-9) → 3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-7-(p-iodobenzyl)-4-desmethylwyosine (865447-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / imidazole / dimethylformamide; tetrahydrofuran / 20 °C

2.1: NaH / dimethylsulfoxide / 1 h / 20 °C

2.2: 85 percent / dimethylsulfoxide / 20 °C

3.1: 57 percent / K₂CO₃ / dimethylformamide / 2.5 h / 20 °C

With 1H-imidazole; sodium hydride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-869905

upstream raw materials:

3',5'-O-di-tert-butyldimethylsilyl-2'-deoxy-4-desmethylwyosine

1-bromomethyl-4-iodobenzene

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

2'-Deoxyguanosine

Downstream raw materials:

3',5'-O-di-tert-butyldimethylsilyl-2-N-(p-iodobenzyl)-2'-deoxyguanosine