(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

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Chemical Name:(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid
CAS No.:78834-37-4
Molecular Formula:C₅₉H₇₇N₇O₁₂
Molecular Weight:1076.3
Hs Code.:

(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Synonyms:(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

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Chemical Property of (S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

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Technology Process of (S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

There total 11 articles about (S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78834-34-1
C₆₆H₈₃N₇O₁₂

: 78834-37-4
(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; for 12h; Ambient temperature;
DOI:10.1246/bcsj.57.3210

Reference yield:

: 95783-01-0
(S)-1-((S)-2-{(S)-2-[(S)-5-Benzyloxycarbonylamino-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

: 78834-37-4
(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: HCl, anisole / dioxane / 0.5 h / Ambient temperature

2: 1-hydroxybenzotriazole, (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

3: 88 percent / 2M aq. NaOH / methanol; dioxane / 12 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; chloroform;
DOI:10.1246/bcsj.57.3210

Reference yield:

: (S)-1-[(S)-2-(2,2-Dimethyl-propoxycarbonylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester

: 78834-37-4
(S)-1-{(S)-2-[(S)-2-((S)-5-Benzyloxycarbonylamino-2-{(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: HCl, anisole / dioxane / 0.5 h / Ambient temperature

2: 1-hydroxybenzotriazole, (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

3: HCl, anisole / dioxane / 0.5 h / Ambient temperature

4: 1-hydroxybenzotriazole, (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

5: HCl, anisole / dioxane / 0.5 h / Ambient temperature

6: 1-hydroxybenzotriazole, (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

7: HCl, anisole / dioxane / 0.5 h / Ambient temperature

8: 1-hydroxybenzotriazole, (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 2 h; room temperature, overnight

9: 88 percent / 2M aq. NaOH / methanol; dioxane / 12 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; chloroform;
DOI:10.1246/bcsj.57.3210