(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

Base Information

Chemical Name:(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol
CAS No.:164061-64-7
Molecular Formula:C₁₄H₁₉N₃O₃
Molecular Weight:277.323
Hs Code.:

Synonyms:(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

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Technology Process of (S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

There total 1 articles about (S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 111853-55-5
(S,S)-3,5-bis(1-hydroxyethyl)-1H-1,2,4-triazole

: 824-94-2
p-methoxybenzyl chloride

: 164061-64-7
(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; at 60 ℃; for 3h;
DOI:10.1055/s-1994-25644

Reference yield:

: 164061-58-9
C₃₂H₃₉N₃O₉S₂

: 164061-64-7
(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

: (2S,7S,12S,17S)-10,20-Bis-(4-methoxy-benzyl)-2,7,12,17-tetramethyl-3,6,13,16-tetraoxa-9,10,19,20,21,22-hexaaza-tricyclo[16.2.1.1^8,11]docosa-1⁽²¹⁾,8,11⁽²²⁾,18-tetraene

: (2S,7S,12S,17S)-10,19-Bis-(4-methoxy-benzyl)-2,7,12,17-tetramethyl-3,6,13,16-tetraoxa-9,10,19,20,21,22-hexaaza-tricyclo[16.2.1.1^8,11]docosa-1⁽²⁰⁾,8,11⁽²²⁾,18⁽²¹⁾-tetraene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 70 ℃; for 120h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; adding ca. 5 h at 70 deg C;
DOI:10.1055/s-1994-25644

Reference yield:

: 164061-64-7
(S)-1-[5-((S)-1-Hydroxy-ethyl)-2-(4-methoxy-benzyl)-2H-[1,2,4]triazol-3-yl]-ethanol

: (2S,7S,12S,17S)-10-(4-Methoxy-benzyl)-2,7,12,17-tetramethyl-3,6,13,16-tetraoxa-9,10,19,20,21,22-hexaaza-tricyclo[16.2.1.1^8,11]docosa-1⁽²¹⁾,8,11⁽²²⁾,18-tetraene

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, (60percent in min. oil) / 1.) THF, 70 deg C, 30 min, 2.) THF, 70 deg C, 24 h

2: conc. HCl / methanol / 5 h / Heating

3: 70 percent / Et₃N / CH₂Cl₂ / 0 deg C, 1 h; 0 deg C to RT

4: 25 percent / NaH (60percent in min. oil) / dimethylformamide / 120 h / Ambient temperature; adding ca. 3 h at RT

5: 82 percent / NaNO₂, 6N HCl / 2 h / 0 °C

With hydrogenchloride; sodium hydride; triethylamine; sodium nitrite; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1994-25644