tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate
CAS No.:952685-54-0
Molecular Formula:C₂₉H₄₇N₃O₅Si
Molecular Weight:545.795
Hs Code.:

Synonyms:tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

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Chemical Property of tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

There total 6 articles about tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952685-53-9
tert-butyl (2S,3R)-4-(4-cyanobenzylamino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: 952685-54-0
tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 10406-25-4
4-aminobenzyl cyanide

: 952685-54-0
tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / Heating / reflux

2: triethylamine / dichloromethane / 20 °C

With triethylamine; In dichloromethane; acetonitrile;

Reference yield:

: 118388-73-1
(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate

: 952685-54-0
tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; diethyl ether / 0 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 0.75 h / 0 - 20 °C

3: sodium hydroxide / ethanol / 1 h

4: acetonitrile / Heating / reflux

5: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; acetonitrile;