Fluciclovine

Base Information

Chemical Name:Fluciclovine
CAS No.:222727-43-7
Molecular Formula:C₅H₈FNO₂
Molecular Weight:133.122
Hs Code.:
UNII:YKG0YF688X
DSSTox Substance ID:DTXSID301027797
Nikkaji Number:J1.925.863G
Wikidata:Q27294558
ChEMBL ID:CHEMBL1908917,CHEMBL1908889
Mol file:222727-43-7.mol

Synonyms:(18F)GE-148;(1R,3R)-1-amino-3(18F)fluorocyclobutane-1-carboxylic acid;1-amino-3-fluorocyclobutane-1-carboxylic acid;anti-(18F)FACBC;Axumin;cyclobutanecarboxylic acid, 1-amino-3-(fluoro-18F)-, trans-;F(18)-FACBC;F(18)1-amino-3-fluorocyclobutane-1-carboxylic acid;F-FACBC;fluciclovine (18F);fluciclovine F 18;fluciclovine F-18;GE-148 (18F);GE-148 F-18;NMK 36;NMK-36;NMK36 cpd

Suppliers and Price of Fluciclovine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
trans-1-Amino-3-fluoro-cyclobutanecarboxylic Acid
2.5mg
$ 566.00

TRC
trans-1-Amino-3-fluoro-cyclobutanecarboxylicAcid
25mg
$ 1980.00

Synthonix
trans-1-Amino-3-fluoro-cyclobutanecarboxylicacid 95+%
500mg
$ 1220.00

Matrix Scientific
trans-1-Amino-3-fluoro-cyclobutanecarboxylicacid 95+%
1g
$ 2855.00

Crysdot
trans-1-Amino-3-fluorocyclobutanecarboxylicacid 95+%
1g
$ 772.00

Chemenu
trans-1-Amino-3-fluoro-cyclobutanecarboxylicacid 95%
1g
$ 729.00

American Custom Chemicals Corporation
TRANS-1-AMINO-3-FLUOROCYCLOBUTANECARBOXYLIC ACID 95.00%
5MG
$ 504.11

AK Scientific
trans-1-Amino-3-fluorocyclobutanecarboxylicacid
1g
$ 3904.00

Total 9 raw suppliers

Chemical Property of Fluciclovine

Chemical Property:

PSA：63.32000
LogP:0.60070
Storage Temp.:2-8°C
XLogP3:-2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:133.05390666
Heavy Atom Count:9
Complexity:142

Purity/Quality:

97% ^*data from raw suppliers

trans-1-Amino-3-fluoro-cyclobutanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CC1(C(=O)O)N)F
Recent EU Clinical Trials:PredicTive value of FluoR-18 PSMA-1007 PET/CT and anti-3-[18F] FACBC PET/CT before PLND for lymph nodE staging in primary pRostate cancer
Uses trans-1-Amino-3-fluoro-cyclobutanecarboxylic Acid is a precursor for labelled anti-[F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid; a PET tracer for tumor delineation.

Technology Process of Fluciclovine

There total 8 articles about Fluciclovine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 222727-41-5
1-t-butyl carbamate-3-fluoro-1-cyclobutane-1-carboxylic acid methyl ester

: 222727-43-7
1-amino-3-fluorocyclobutane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; at 115 ℃; for 2h;
DOI:10.1002/(SICI)1099-1344(199903)42:3<215::AID-JLCR180>3.0.CO;2-0

Reference yield: 58.0%

: 1-[N-(phthaloyl)amino]-3-fluorocyclobutanecarboxylic acid methyl ester

: 222727-43-7
1-N-amino-3-fluorocyclobutanecarboxylic acid

Guidance literature:: 1-[N-(phthaloyl)amino]-3-fluorocyclobutanecarboxylic acid methyl ester; With hydrazine hydrate; at 75 ℃; for 0.5h;

With hydrogenchloride; water; pH=7;
DOI:10.1016/j.bmc.2009.01.032