N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Base Information

Chemical Name:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester
CAS No.:609846-88-0
Molecular Formula:C₃₁H₃₅N₅O₅
Molecular Weight:557.649
Hs Code.:

Synonyms:N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Suppliers and Price of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

There total 8 articles about N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 441764-53-0
(R)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester

: 609846-88-0
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 65 °C

2.1: H₂ / Pd/C / tetrahydrofuran / 18 h

3.1: H₂O / 7 h / 60 °C

4.1: toluene / 24 h / 70 °C

4.2: 55 percent / H₂ / Pd/C / tetrahydrofuran / 1.17 h

5.1: aq. LiOH / methanol

6.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: 441764-51-8
(R)-2-allyloxysuccinic acid dimethyl ester

: 609846-88-0
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: OsO₄; N-methyl morpholine-N-oxide / tetrahydrofuran; H₂O

2.1: NaIO₄ / tetrahydrofuran; H₂O

3.1: toluene / 65 °C

4.1: H₂ / Pd/C / tetrahydrofuran / 18 h

5.1: H₂O / 7 h / 60 °C

6.1: toluene / 24 h / 70 °C

6.2: 55 percent / H₂ / Pd/C / tetrahydrofuran / 1.17 h

7.1: aq. LiOH / methanol

8.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; sodium periodate; osmium(VIII) oxide; water; hydrogen; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990

Reference yield:

: (R)-2-(2,3-Dihydroxy-propoxy)-succinic acid dimethyl ester

: 609846-88-0
N-(4-benzyloxycarbonylamidino-benzyl)-2-[(R)-3-oxo-4-(3-phenyl-propylamino)-morpholin-2-yl]-acetamide acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaIO₄ / tetrahydrofuran; H₂O

2.1: toluene / 65 °C

3.1: H₂ / Pd/C / tetrahydrofuran / 18 h

4.1: H₂O / 7 h / 60 °C

5.1: toluene / 24 h / 70 °C

5.2: 55 percent / H₂ / Pd/C / tetrahydrofuran / 1.17 h

6.1: aq. LiOH / methanol

7.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium PF₆; DIPEA / dimethylformamide / 1.67 h

With lithium hydroxide; sodium periodate; water; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0307990