ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Base Information

Chemical Name:ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate
CAS No.:1263766-34-2
Molecular Formula:C₂₅H₃₂N₂O₅
Molecular Weight:440.539
Hs Code.:

Synonyms:ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Suppliers and Price of ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

There total 5 articles about ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1263766-33-1
ethyl 3-(3-formyl-1-iodo-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

: 159624-15-4
tert-butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

: 1263766-34-2
ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; at 20 - 40 ℃; for 37h; Inert atmosphere;
DOI:10.1039/c0ob00572j

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1263766-34-2
ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: dilauryl peroxide / 1,2-dichloro-ethane / 7 h / Inert atmosphere; Reflux

3.1: iodine; silver trifluoroacetate / chloroform / 16 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran; water / 37 h / 20 - 40 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dilauryl peroxide; iodine; silver trifluoroacetate; sodium hydride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00572j

Reference yield:

: 1263766-36-4
ethyl 3-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

: 1263766-34-2
ethyl 3-(1-(2-tert-butoxycarbonylamino)phenyl)-(3-formyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; silver trifluoroacetate / chloroform / 16 h / 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran; water / 37 h / 20 - 40 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; silver trifluoroacetate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; chloroform; water;
DOI:10.1039/c0ob00572j