Technology Process of (2R,3R)-4-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-2-methylbutanal
There total 12 articles about (2R,3R)-4-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-2-methylbutanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -78 ℃;
DOI:10.1002/ejoc.202000156
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: (R,R)-ruthenium complex; Et3N; HCO2H / CH2Cl2 / 16 h / 20 °C
2.1: bis(trimethylsilylperoxide); rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; SnCl4 / molecular sieves 4 Angstroem / CH2Cl2 / 12 h / 20 °C
2.2: acetic acid / tetrahydrofuran; H2O / 18 h / 20 °C
3.1: 2,6-lutidine / CH2Cl2 / 1 h / -78 °C
4.1: DIBAL-H / toluene; hexane / 1 h / -78 °C
5.1: oxalyl chloride; DMSO / CH2Cl2 / 0.33 h / -78 °C
With
2,6-dimethylpyridine; formic acid; oxalyl dichloride; bis-trimethylsilanyl peroxide; rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; (R,R)-ruthenium; tin(IV) chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
4 A molecular sieve;
In
hexane; dichloromethane; toluene;
2.1: Baeyer-Villiger oxidation / 5.1: Swern reacrion;
DOI:10.1021/jo035068m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C
1.2: 72 percent / tetrahydrofuran / 1.75 h / -78 - 20 °C
2.1: (R,R)-ruthenium complex; Et3N; HCO2H / CH2Cl2 / 16 h / 20 °C
3.1: bis(trimethylsilylperoxide); rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; SnCl4 / molecular sieves 4 Angstroem / CH2Cl2 / 12 h / 20 °C
3.2: acetic acid / tetrahydrofuran; H2O / 18 h / 20 °C
4.1: 2,6-lutidine / CH2Cl2 / 1 h / -78 °C
5.1: DIBAL-H / toluene; hexane / 1 h / -78 °C
6.1: oxalyl chloride; DMSO / CH2Cl2 / 0.33 h / -78 °C
With
2,6-dimethylpyridine; formic acid; oxalyl dichloride; bis-trimethylsilanyl peroxide; rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; (R,R)-ruthenium; tin(IV) chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide;
4 A molecular sieve;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
3.1: Baeyer-Villiger oxidation / 6.1: Swern reacrion;
DOI:10.1021/jo035068m
![(R)-4-benzyl-3-{(2R,3R)-4-(benzyloxy)-3-[(tert-butyldimethylsilyl)oxy]-methylbutanoyl}oxazolidin-2-one](/Databaselist/images/loading.webp)
