N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Base Information

• Chemical Name: N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide
• CAS No.: 128495-68-1
• Molecular Formula: BrH*C₁₉H₂₄FNO
• Molecular Weight: 382.316
• Mol file: 128495-68-1.mol

Synonyms:N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Chemical Property of N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

There total 12 articles about N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine (128495-60-3) → N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide (128495-68-1)

Guidance literature:

With hydrogen bromide; at 125 - 130 ℃; for 3h;

DOI:10.1021/jm00171a014

Reference yield:

1-fluoro-2-methoxy-4-methylbenzene (63762-78-7) → N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide (128495-68-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 70 percent / potassium permanganate, pyridine / H₂O / 1.) 50 deg C, 3 h, 2.) RT, 3 h

2: 95 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

3: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

4: 84 percent / Na₂CO₃, methylamine hydrochloride / ethanol / 72 h / Ambient temperature

5: 54 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

6: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature

7: 87 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

8: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature

9: 92 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

10: 83 percent / 48percent HBr / 3 h / 125 - 130 °C

With pyridine; potassium permanganate; lithium aluminium tetrahydride; hydrogen bromide; methylamine hydrochloride; sodium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

DOI:10.1021/jm00171a014

Reference yield:

2-fluoro-5-methylphenol (63762-79-8) → N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide (128495-68-1)

Guidance literature:

Multi-step reaction with 11 steps

1: 84 percent / K₂CO₃ / acetone / 5 h / Heating

2: 70 percent / potassium permanganate, pyridine / H₂O / 1.) 50 deg C, 3 h, 2.) RT, 3 h

3: 95 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

4: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

5: 84 percent / Na₂CO₃, methylamine hydrochloride / ethanol / 72 h / Ambient temperature

6: 54 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

7: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature

8: 87 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

9: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature

10: 92 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

11: 83 percent / 48percent HBr / 3 h / 125 - 130 °C

With pyridine; potassium permanganate; lithium aluminium tetrahydride; hydrogen bromide; methylamine hydrochloride; sodium carbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetone;

DOI:10.1021/jm00171a014

upstream raw materials:

N-n-propyl-N-(2-phenylethyl)-2-(4-fluoro-3-methoxyphenyl)ethylamine

1-fluoro-2-methoxy-4-methylbenzene

2-fluoro-5-methylphenol

3-amino-4-fluorotoluene

Refernces