2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Base Information

Chemical Name:2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate
CAS No.:85939-39-5
Molecular Formula:C₂₅H₂₈N₂O₆S
Molecular Weight:484.573
Hs Code.:

Synonyms:2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Chemical Property of 2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

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Technology Process of 2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

There total 5 articles about 2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 85923-43-9
2-chloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

: 85939-39-5
2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: With cyanocobalamin; ammonium chloride; zinc; In tetrahydrofuran; water; for 36h; Heating;
DOI:10.1021/ja00352a037

Reference yield:

: 5416-80-8
2-methyl-1H-indole-3-carbaldehyde

: 85939-39-5
2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: 2.) Na₂SO₄ / 1.) benzene, 1 h, 2.) 2 h

3: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

4: 63 percent / aq. vitamin B₁₂, ammonium chloride, zinc / H₂O; tetrahydrofuran / 36 h / Heating

With 1H-imidazole; cyanocobalamin; ammonium chloride; sodium hydride; sodium sulfate; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; water; chlorobenzene;
DOI:10.1021/ja00352a037

Reference yield:

: 85923-42-8
N-<<(4-methoxybenzenesulfonyl)-2-methyl-1H-indol-3-yl>methylene>-4-pentenylamine

: 85939-39-5
2-hydroxyethyl cis-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / diisopropylethylamine / chlorobenzene / 1.) 0 deg C -> 135 deg C, 35 min, 2.) 135 deg C, 40 min

2: 63 percent / aq. vitamin B₁₂, ammonium chloride, zinc / H₂O; tetrahydrofuran / 36 h / Heating

With cyanocobalamin; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; water; chlorobenzene;
DOI:10.1021/ja00352a037