N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

Base Information

Chemical Name:N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine
CAS No.:457880-59-0
Molecular Formula:C₃₃H₃₃N₅O₇
Molecular Weight:611.654
Hs Code.:

N<sup>2</sup>-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

Synonyms:N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

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Chemical Property of N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

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Technology Process of N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

There total 12 articles about N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1054622-43-3
Acetic acid (2R,3R,5S)-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-tetrahydro-pyran-3-yl ester

: 457880-59-0
N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; methanol; at 4 ℃; for 0.133333h;
DOI:10.1002/1522-2675(200205)85:5<1443::AID-HLCA1443>3.0.CO;2-U

Reference yield:

: 6894-01-5
benzyl O²,O⁴-phenylboranediyl-α-D-xylopyranoside

: 457880-59-0
N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

Guidance literature:: Multi-step reaction with 10 steps

1.1: Et₃N / 1 h / 25 °C

2.1: NaOMe / methanol / 1 h / 25 °C

2.2: 8.5 g / LiAlH₄ / tetrahydrofuran / 30 h / 24 °C

3.1: 9.5 g / iPr₂NEt; AgNO₃ / CH₂Cl₂ / -78 - 25 °C

4.1: H₂ / Pd(OH)2/C / ethanol / 48 h / 25 °C / 4500.36 Torr

5.1: 16.0 g / pyridine / 25 °C

6.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 0.75 h / 60 °C

6.2: Et₃SiOTf / benzene / 1.5 h / 45 °C

7.1: 9.13 g / Et₄NF*2H₂O; AcOH / acetonitrile / 0.33 h / 25 °C

8.1: AgNO₃ / CH₂Cl₂ / 0.5 h / 25 °C

9.1: NaNO₂ / dimethylsulfoxide / 4 h / 75 °C

10.1: 2.17 g / NaOH; water / tetrahydrofuran; methanol / 0.13 h / 4 °C

With pyridine; sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; water; hydrogen; sodium methylate; tetraethylammonium fluoride; silver nitrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/1522-2675(200205)85:5<1443::AID-HLCA1443>3.0.CO;2-U

Reference yield:

: 112482-91-4
benzyl 3-deoxy-α-D-xylopyranoside

: 457880-59-0
N²-acetyl-9-[3'-deoxy-4'-O-(4,4'-dimethoxytrityl)-β-D-ribopyranosyl]guanine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 9.5 g / iPr₂NEt; AgNO₃ / CH₂Cl₂ / -78 - 25 °C

2.1: H₂ / Pd(OH)2/C / ethanol / 48 h / 25 °C / 4500.36 Torr

3.1: 16.0 g / pyridine / 25 °C

4.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 0.75 h / 60 °C

4.2: Et₃SiOTf / benzene / 1.5 h / 45 °C

5.1: 9.13 g / Et₄NF*2H₂O; AcOH / acetonitrile / 0.33 h / 25 °C

6.1: AgNO₃ / CH₂Cl₂ / 0.5 h / 25 °C

7.1: NaNO₂ / dimethylsulfoxide / 4 h / 75 °C

8.1: 2.17 g / NaOH; water / tetrahydrofuran; methanol / 0.13 h / 4 °C

With pyridine; sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; water; hydrogen; tetraethylammonium fluoride; silver nitrate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/1522-2675(200205)85:5<1443::AID-HLCA1443>3.0.CO;2-U