2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

Base Information

Chemical Name:2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid
CAS No.:186908-18-9
Molecular Formula:C₂₇H₃₁N₃O₆
Molecular Weight:493.56
Hs Code.:

Synonyms:2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

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Chemical Property of 2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

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Technology Process of 2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

There total 8 articles about 2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186908-13-4
2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid ethyl ester

: 186908-18-9
2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Ambient temperature;

Reference yield:

: 131583-56-7
1-[1-(4-Hydroxy-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

: 186908-18-9
2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent NaH / paraffin; dimethylformamide / 1 h / 60 °C

2: 41 percent / LAH / tetrahydrofuran / 0 deg C to 10 deg C, 2 h, RT, 1 h

3: 97 percent / pyridine / CHCl₃ / 25 h / Ambient temperature

4: 81 percent / NaI / acetone / 10 h / Heating

5: 68 percent / 60 percent NaH / paraffin; dimethylformamide / 1.5 h / 60 - 70 °C

6: 1 N NaOH / ethanol / 2 h / Ambient temperature

7: benzene / 2 h / Heating

8: 90 percent / 1 N NaOH / ethanol / 2 h / Ambient temperature

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; sodium hydride; sodium iodide; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide; acetone; paraffin; benzene;

Reference yield:

: 155436-86-5
1-{1-[4-(2-Hydroxy-ethoxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

: 186908-18-9
2-Acetylamino-4-{4-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenoxy}-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / pyridine / CHCl₃ / 25 h / Ambient temperature

2: 81 percent / NaI / acetone / 10 h / Heating

3: 68 percent / 60 percent NaH / paraffin; dimethylformamide / 1.5 h / 60 - 70 °C

4: 1 N NaOH / ethanol / 2 h / Ambient temperature

5: benzene / 2 h / Heating

6: 90 percent / 1 N NaOH / ethanol / 2 h / Ambient temperature

With pyridine; sodium hydroxide; sodium hydride; sodium iodide; In ethanol; chloroform; N,N-dimethyl-formamide; acetone; paraffin; benzene;