5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester
• CAS No.: 1026686-05-4
• Molecular Formula: C₆₂H₆₂N₂O₄
• Molecular Weight: 899.185

Synonyms:5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester

Chemical Property of 5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of 5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 1 articles about 5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyl-5-methanesulfonyloxy-2,8-bis-(9-phenyl-9H-fluoren-9-ylamino)-nonanedioic acid di-tert-butyl ester → 5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester (1026686-05-4)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1021/jo980596x

Reference yield:

5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester (1026686-05-4) → (2S,5R)-5-((1S,3S)-3-Amino-1-benzyl-3-carboxy-propyl)-pyrrolidine-2-carboxylic acid

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jo980596x

Reference yield:

5-[1-benzyl-3-tert-butoxycarbonyl-3-(9-phenyl-9H-fluoren-9-ylamino)-propyl]-1-(9-phenyl-9H-fluoren-9-yl)-pyrrolidine-2-carboxylic acid tert-butyl ester (1026686-05-4) → (3S,6S,8S,8aR)-6-Amino-8-benzyl-5-oxo-octahydro-indolizine-3-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 48 h / 20 °C

2: SOCl₂ / 4 h / -5 - 50 °C

3: Et₃N / CH₂Cl₂ / 24 h / 20 °C

With thionyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane; 1: solvolysis / 2: Esterification / 3: Cyclization;

DOI:10.1021/jo980596x

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