1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane

Base Information

• Chemical Name: 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane
• CAS No.: 1019853-25-8
• Molecular Formula: C₁₈H₁₉NO₃S
• Molecular Weight: 329.42
• Mol file: 1019853-25-8.mol

Synonyms:1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane

Chemical Property of 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane

There total 2 articles about 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (206759-70-8) + diphenyl(vinyl)sulfonium trifluoromethanesulfonate → 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (1019853-25-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol800318h

Reference yield: 65.0%

3-(7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-2-vinyl-2-thionia-bicyclo[2.2.1]heptane trifluoromethanesulfonate + (S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide (206759-70-8) → 1(R),2(S),5(S)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (1019853-25-8) + 1(S),2(S),5(R)-2-methyl-1-phenyl-3-(toluene-4-sulfonyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (1019853-24-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 18h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol800318h

upstream raw materials:

(S)-4-methyl-N-(1-methyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide