trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide

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Chemical Name:trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide
CAS No.:1236792-16-7
Molecular Formula:C₂₃H₂₈N₆O₄
Molecular Weight:452.513
Hs Code.:

Synonyms:trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide

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Chemical Property of trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide

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Technology Process of trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide

There total 2 articles about trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22059-22-9,118453-50-2,118464-69-0,118493-85-9,117771-39-8,1141922-26-0
N-hydroxyacetamidine

: 1109276-89-2
2-((1r,4r)-4-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid

: 1236792-16-7
trans-2-{4-[4-(4-amino-5-oxo-7,8-dihydro-5H-9-oxa-1,3,6-triazabenzocyclohepten-6-yl)phenyl]cyclohexyl}-N-{1-[(E)-hydroxyimino]-ethyl}-acetamide

Guidance literature:: 2-((1r,4r)-4-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid; With oxalyl dichloride; In 1,2-dichloro-ethane; at 20 ℃; Cooling with ice;

N-hydroxyacetamidine; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 22059-22-9,118453-50-2,118464-69-0,118493-85-9,117771-39-8,1141922-26-0
N-hydroxyacetamidine

: 1109276-89-2
2-((1r,4r)-4-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid

: 1236792-16-7
C₂₃H₂₈N₆O₄

Guidance literature:: 2-((1r,4r)-4-(4-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid; With oxalyl dichloride; In 1,2-dichloro-ethane; at 20 ℃; Cooling with ice;

N-hydroxyacetamidine; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmc.2013.06.045