N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Base Information

Chemical Name:N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide
CAS No.:374601-02-2
Molecular Formula:C₂₉H₃₀BrN₃O₄S
Molecular Weight:596.545
Hs Code.:

Synonyms:N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Suppliers and Price of N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

There total 7 articles about N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 32779-36-5
5-Bromo-2-chloropyrimidine

: 374600-28-9
4-tert-butyl-N-(3-(2-hydroxyethoxy)-2-(4-methylphenyl)phenyl)benzenesulfonamide

: 374601-02-2
N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: 4-tert-butyl-N-(3-(2-hydroxyethoxy)-2-(4-methylphenyl)phenyl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl acetamide; at 0 ℃; for 0.333333h;

5-Bromo-2-chloropyrimidine; In N,N-dimethyl acetamide; at 20 ℃; for 7h; Further stages.;
DOI:10.1021/jm0102304

Reference yield:

: 15084-51-2
4-tert-butylbenzenesulfonyl chloride

: 374601-02-2
N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / pyridine / 2 h / 20 °C

2.1: 93 percent / H₂; H₂O / 10percent Pd/C / ethanol / 3 h / 20 °C

3.1: NaH / N,N-dimethyl-acetamide / 0.33 h / 0 °C

3.2: 92 percent / N,N-dimethyl-acetamide / 7 h / 20 °C

With pyridine; water; hydrogen; sodium hydride; 10percent Pd/C; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm0102304

Reference yield:

: 603-84-9
2-chloro-3-nitrophenol

: 374601-02-2
N-(3-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-2-(4-methylphenyl)phenyl)-4-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / PPh₃; DEAD / tetrahydrofuran / 2 h / 0 °C

2.1: 89 percent / PdCl₂(PPh₃)2 / dioxane / 4 h / 20 °C

3.1: 87 percent / Fe; 10percent aq. HCl / ethanol / 3.5 h / Heating

4.1: 100 percent / pyridine / 2 h / 20 °C

5.1: 93 percent / H₂; H₂O / 10percent Pd/C / ethanol / 3 h / 20 °C

6.1: NaH / N,N-dimethyl-acetamide / 0.33 h / 0 °C

6.2: 92 percent / N,N-dimethyl-acetamide / 7 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; water; hydrogen; iron; sodium hydride; triphenylphosphine; diethylazodicarboxylate; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm0102304