[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

Base Information

Chemical Name:[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride
CAS No.:116194-23-1
Molecular Formula:C₃₆H₃₈N₄O₅*ClH
Molecular Weight:643.182
Hs Code.:

Synonyms:[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

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Chemical Property of [(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

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Technology Process of [(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

There total 6 articles about [(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116194-15-1
[(S)-5-(4-Benzoyl-phenylcarbamoyl)-5-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentyl]-carbamic acid benzyl ester

: 116194-23-1
[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1248/cpb.36.1289

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 116194-23-1
[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / ethyl chloroformate, Et₃N / tetrahydrofuran / 18 h / 4 °C

2: HCl / dioxane

3: 63 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

4: HCl / dioxane

With hydrogenchloride; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.1289

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 116194-23-1
[(S)-5-((S)-2-Amino-3-phenyl-propionylamino)-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

2: HCl / dioxane

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.1289