(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Base Information

• Chemical Name: (2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal
• CAS No.: 1037070-06-6
• Molecular Formula: C₂₀H₂₆N₂O₅S₂
• Molecular Weight: 438.569
• Mol file: 1037070-06-6.mol

Synonyms:(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Chemical Property of (2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

There total 1 articles about (2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal (140647-02-5) + propargyl bromide (106-96-7) → (2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal (1037070-06-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.04.006

Reference yield: 90.0%

(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal (1037070-06-6) + 3-(5-azidopentyloxy)-17-hydroxy-1,3,5(10)-estratriene (1307900-64-6) → C43H59N5O7S2 (1307901-07-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2011.03.015

Reference yield: 88.0%

(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal (1037070-06-6) + 3-(3-azidopropyloxy)-17-hydroxy-1,3,5(10)-estratriene (1307900-63-5) → C41H55N5O7S2 (1307901-03-6)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2011.03.015

upstream raw materials:

(2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

propargyl bromide

Downstream raw materials:

C₄₂H₅₉N₇O₁₀S₄

C₄₀H₅₅N₇O₁₀S₄

C₄₁H₅₇N₇O₁₀S₄

C₄₃H₆₁N₇O₁₀S₄