trans-3Hydroxymethylnicotine

Base Information

• Chemical Name: trans-3Hydroxymethylnicotine
• CAS No.: 33224-02-1
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.261
• Mol file: 33224-02-1.mol

Synonyms:3-Pyrrolidinemethanol,1-methyl-2-(3-pyridinyl)-, (2S-trans)-; trans-3'-(Hydroxymethyl)nicotine

Chemical Property of trans-3Hydroxymethylnicotine

Chemical Property:

• PSA: 36.36000
• LogP: 1.00460
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere

Purity/Quality:

98% ^*data from raw suppliers

TRANS-3'-HYDROXYMETHYLNICOTINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-3Hydroxymethylnicotine is a useful compound for making immunogens for the production of antibodies to nicotine.

Technology Process of trans-3Hydroxymethylnicotine

There total 2 articles about trans-3Hydroxymethylnicotine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-4-cotininecarboxylic acid + BH3.THF → racemic trans-3'-hydroxymethylnicotine + trans-3'-Hydroxymethylnicotin (33224-02-1)

Guidance literature:

With hydrogenchloride; NaOH; In tetrahydrofuran; methanol; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

→ trans-3'-Hydroxymethylnicotin (33224-02-1)

Guidance literature:

(9), LiAlH4;

DOI:10.1021/jo00973a046

Refernces

• 1、 -. "MODIFIED NICOTINIC COMPOUNDS AND RELATED METHODS". . . Retrieved 2012/05/20.