4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Base Information

Chemical Name:4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol
CAS No.:1312806-25-9
Molecular Formula:C₂₁H₂₂ClFN₄O₂
Molecular Weight:416.883
Hs Code.:

Synonyms:4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

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Chemical Property of 4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Chemical Property:

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Technology Process of 4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

There total 7 articles about 4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: N-(4-chloro-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

: 1312806-25-9
4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Guidance literature:: With pyridine hydrochloride; at 190 - 200 ℃; for 1.33333h;
DOI:10.1016/j.bmcl.2011.04.049

Reference yield:

: 57946-56-2
2-fluoro-4-chloroaniline

: 1312806-25-9
4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux

2: trifluoroacetic acid / 1 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C

6: pyridine hydrochloride / 1.33 h / 190 - 200 °C

With hydrogenchloride; sodium triacetoxyborohydride; pyridine hydrochloride; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.049

Reference yield:

: 162364-72-9
7-benzyloxy-4-chloro-6-methoxyquinazoline

: 1312806-25-9
4-((4-chloro-2-fluorophenyl)amino)-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux

2: trifluoroacetic acid / 1 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 90 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: sodium triacetoxyborohydride; acetic acid / methanol; dichloromethane; water / 2 h / 20 °C

6: pyridine hydrochloride / 1.33 h / 190 - 200 °C

With hydrogenchloride; sodium triacetoxyborohydride; pyridine hydrochloride; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.049