1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide

Base Information

• Chemical Name: 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide
• CAS No.: 74356-64-2
• Molecular Formula: Br*C₁₆H₂₁BrNO₂
• Molecular Weight: 419.156
• Mol file: 74356-64-2.mol

Synonyms:1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide

Chemical Property of 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide

There total 2 articles about 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5,5-dibromo-2-<2-(dimethylamino)ethyl>-2-(4-methoxyphenyl)cyclopentanone hydrobromide (74356-63-1) → 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide (74356-64-2)

Guidance literature:

With ammonia; In water; at 5 ℃; for 2h;

DOI:10.1021/jm00181a005

Reference yield:

2-(4-methoxyphenyl)-2-<2-(dimethylamino)ethyl>cyclopentanone hydrobromide (61321-34-4) → 1-bromo-5-(4-methoxyphenyl)-2-methyl-8-oxo-2-azabicyclo<3.2.1>octane methobromide (74356-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / bromine / acetic acid / Ambient temperature

2: 75 percent / ammonia / H₂O / 2 h / 5 °C

With ammonia; bromine; In water; acetic acid;

DOI:10.1021/jm00181a005

upstream raw materials:

5,5-dibromo-2-<2-(dimethylamino)ethyl>-2-(4-methoxyphenyl)cyclopentanone hydrobromide

2-(4-methoxyphenyl)-2-<2-(dimethylamino)ethyl>cyclopentanone hydrobromide