[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

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Chemical Name:[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine
CAS No.:1232399-14-2
Molecular Formula:C₂₉H₃₄N₆O₃
Molecular Weight:514.627
Hs Code.:

Synonyms:[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

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Chemical Property of [2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

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Technology Process of [2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

There total 6 articles about [2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: [2-methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine trifluoroacetic acid

: 1232399-14-2
[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

Guidance literature:: With sodium hydrogencarbonate; In water;
DOI:10.1021/jm200758k

Reference yield:

: 761440-91-9
2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenylamine

: 1232816-20-4
7-(2-methoxyphenyl)-2-(methylsulfinyl)pyrrolo[2,1-f][1,2,4]triazine

: 1232399-14-2
[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 2-methoxy-ethanol; at 200 ℃; for 8h; Microwave irradiation;

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232399-14-2
[2-methoxy-4-(4-(morpholin-4-yl)-piperidin-1-yl)-phenyl]-[7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

3.2: 0.08 h

4.1: sodium hydrogencarbonate / water

With palladium diacetate; sodium hydrogencarbonate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm200758k