benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

Base Information

Chemical Name:benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate
CAS No.:948894-99-3
Molecular Formula:C₃₁H₄₃N₃O₅Si
Molecular Weight:565.785
Hs Code.:

Synonyms:benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

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Chemical Property of benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

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Technology Process of benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

There total 9 articles about benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 743461-21-4
5-((1R)-2-amino-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-8-hydroxyquinolin-2(1H)-one

: phenylmethyl 2-(4-oxopiperidyl)acetate

: 948894-99-3
benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

Guidance literature:: 5-((1R)-2-amino-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-8-hydroxyquinolin-2(1H)-one; phenylmethyl 2-(4-oxopiperidyl)acetate; With acetic acid; In 1-methyl-pyrrolidin-2-one; for 14h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; for 24h;

With ammonia; In isopropyl alcohol; acetonitrile;

Reference yield:

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

: 948894-99-3
benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium azide; sodium iodide / dimethyl sulfoxide / 3 h / 65 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3750.38 Torr

4.1: acetic acid / 1-methyl-pyrrolidin-2-one / 14 h / Molecular sieve

4.2: 24 h

With 2,6-dimethylpyridine; sodium azide; hydrogen; acetic acid; sodium iodide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 948894-99-3
benzyl (4-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; sodium iodide / dimethyl sulfoxide / 3 h / 65 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3750.38 Torr

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 14 h / Molecular sieve

3.2: 24 h

With sodium azide; hydrogen; acetic acid; sodium iodide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide;