4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

Base Information

Chemical Name:4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol
CAS No.:1085452-89-6
Molecular Formula:C₂₀H₁₅F₃N₄O₃
Molecular Weight:416.359
Hs Code.:

Synonyms:4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

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Chemical Property of 4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

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Technology Process of 4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

There total 8 articles about 4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1085454-10-9
5-[5-methyl-1-(4-{[tris(1-methylethyl)silyl]oxy}benzyl)-1H-pyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

: 1085452-89-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1085452-89-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / 16 h / 0 - 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 10 °C

3: 1H-imidazole; bromine; triphenylphosphine / diethyl ether; acetonitrile / 0 - 20 °C

4: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; tetrabutyl ammonium fluoride; bromine; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

: 856905-30-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid

: 1085452-89-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenol

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 7 h / 20 - 140 °C

2: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;