methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

Base Information

Chemical Name:methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate
CAS No.:1415647-23-2
Molecular Formula:C₁₄H₈F₂N₂O₃S
Molecular Weight:322.292
Hs Code.:

Synonyms:methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

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Chemical Property of methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

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Technology Process of methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

There total 7 articles about methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415647-04-9
methyl 2-(2-methoxy-2-oxoacetyl)thiophene-3-carboxylate

: 1415647-23-2
methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / tetrahydrofuran; methanol; water / 4 h / 50 °C

2: hydrogenchloride / dichloromethane / 15 h / 40 °C

3: tetrahydrofuran; methanol / 3 h / 60 °C

4: thionyl chloride / benzene / 50 °C

5: benzene / 50 °C

With hydrogenchloride; thionyl chloride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1016/j.tet.2012.10.010

Reference yield:

: 1415647-08-3
2-[methoxy(oxo)acetyl]-3-thienoic acid

: 1415647-23-2
methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; methanol / 3 h / 60 °C

2: thionyl chloride / benzene / 50 °C

3: benzene / 50 °C

With thionyl chloride; In tetrahydrofuran; methanol; benzene;
DOI:10.1016/j.tet.2012.10.010

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1415647-23-2
methyl 5-(2,4-difluorophenyl)-4-oxo-4,5-dihyhydrothieno[2,3-d]pyridazine-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium bromide / 1,4-dioxane / Reflux

2: selenium(IV) oxide / 18 h / 125 °C

3: potassium hydroxide / tetrahydrofuran; methanol; water / 4 h / 50 °C

4: hydrogenchloride / dichloromethane / 15 h / 40 °C

5: tetrahydrofuran; methanol / 3 h / 60 °C

6: thionyl chloride / benzene / 50 °C

7: benzene / 50 °C

With hydrogenchloride; selenium(IV) oxide; thionyl chloride; potassium hydroxide; lithium bromide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; benzene;
DOI:10.1016/j.tet.2012.10.010