3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

Base Information

Chemical Name:3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol
CAS No.:860778-55-8
Molecular Formula:C₁₈H₂₄N₂OS
Molecular Weight:316.467
Hs Code.:

Synonyms:3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

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Chemical Property of 3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

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Technology Process of 3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

There total 5 articles about 3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 860778-54-7
3-[3-amino-4-(2-dimethylcarbamoyl-phenylsulfanyl)-phenyl]-propionic acid ethyl ester

: 860778-55-8
3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

Guidance literature:: With borane-THF; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm050079o

Reference yield:

: 860778-53-6
(E)-3-[4-(2-Dimethylcarbamoyl-phenylsulfanyl)-3-nitro-phenyl]-acrylic acid ethyl ester

: 860778-55-8
3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

Guidance literature:: (E)-3-[4-(2-Dimethylcarbamoyl-phenylsulfanyl)-3-nitro-phenyl]-acrylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 65 ℃; for 3h;

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 163596-75-6
4-bromo-3-nitrobenzaldehyde

: 860778-55-8
3-[3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / acetonitrile / Heating

2: 68 percent / Cs₂CO₃; CuI / toluene / Heating

3: 20 percent / H₂ / Pd(OH)2 / ethanol / 20 h

4: 26 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

With copper(l) iodide; borane-THF; hydrogen; caesium carbonate; palladium dihydroxide; In tetrahydrofuran; ethanol; toluene; acetonitrile; 1: Wittig reaction;
DOI:10.1021/jm050079o