4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

Base Information

Chemical Name:4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile
CAS No.:1426699-48-0
Molecular Formula:C₁₈H₁₅BrClN₅O₂
Molecular Weight:448.706
Hs Code.:

Synonyms:4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

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Chemical Property of 4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

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Technology Process of 4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

There total 5 articles about 4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1426699-45-7
2-bromo-6-chloro-3-ethoxy-4-(1-hydroxyethyl)benzonitrile

: 306960-30-5
4-aminopyrido[2,3-d]pyrimidin-5(8H)-one

: 1426699-48-0
4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

Guidance literature:: 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

2-bromo-6-chloro-3-ethoxy-4-(1-hydroxyethyl)benzonitrile; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 865451-01-0
1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one

: 1426699-48-0
4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; N-Bromosuccinimide / water / 3 h / 60 °C

2.1: N,N-dimethyl-formamide / 18 h / 85 °C

2.2: 3 h / 65 °C

3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

4.2: 50 °C

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; sulfuric acid; sodium hydride; In water; N,N-dimethyl-formamide;

Reference yield:

: 1382997-15-0
1-(3-bromo-5-chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one

: 1426699-48-0
4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 18 h / 85 °C

1.2: 3 h / 65 °C

2.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 50 °C

With methanol; sodium tetrahydroborate; sodium hydride; In N,N-dimethyl-formamide;