(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

Base Information

Chemical Name:(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide
CAS No.:1383661-44-6
Molecular Formula:C₁₉H₁₉N₃O
Molecular Weight:305.379
Hs Code.:

Synonyms:(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

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Chemical Property of (S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

Chemical Property:

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Technology Process of (S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

There total 8 articles about (S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

: (S)-(-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid

: 100-46-9
benzylamine

: 1383661-44-6
(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

Guidance literature:: (S)-(-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2018.03.052

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1383661-44-6
(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water / 1 h / 20 °C

1.2: 3 h / 0 - 20 °C

2.1: ethanol / 5 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4.1: tetrahydrofuran / 4 h / 20 °C

5.1: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / 6 h / Reflux

6.1: trichlorophosphate / 1 h / Reflux

With iron(III) chloride; pyrographite; hydrazine hydrate; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water;
DOI:10.1002/ardp.201100424

Reference yield:

: 182816-05-3
(S)-(+)-1-(2-nitro-benzyl)-5-oxopyrrolidine-2-carboxylic acid

: 1383661-44-6
(S)-(-)-N-benzyl-1,2,3,9-tetrahydropyrrolo[2,1-b]-quinazoline-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2: tetrahydrofuran / 4 h / 20 °C

3: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / 6 h / Reflux

4: trichlorophosphate / 1 h / Reflux

With iron(III) chloride; pyrographite; hydrazine hydrate; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1002/ardp.201100424