3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

Base Information

Chemical Name:3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol
CAS No.:256235-87-7
Molecular Formula:C₃₈H₃₆N₂O₉
Molecular Weight:664.712
Hs Code.:

Synonyms:3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

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Chemical Property of 3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

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Technology Process of 3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

There total 5 articles about 3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 256235-86-6
3-(2-hydroxy-ethoxy)-1,3-bis-(2-nitro-phenyl)-propan-1-ol

: 256235-87-7
3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

Guidance literature:: With TEA; In dichloromethane; at 0 ℃;
DOI:10.1021/ja991300n

Reference yield:

: 577-59-3
2-acetylnitrobenzene

: 256235-87-7
3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃

1.2: 48 percent / NaBH₄

2.1: 45 percent / TEA; DMAP

3.1: 40 percent / NaHCO₃ / 80 °C

4.1: 83 percent / TEA / CH₂Cl₂ / 0 °C

With dmap; TEA; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; 1.1: Addition / 1.2: Reduction / 2.1: Tosylation / 3.1: Etherification / 4.1: Condensation;
DOI:10.1021/ja991300n

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 256235-87-7
3-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-1,3-bis-(2-nitro-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃

1.2: 48 percent / NaBH₄

2.1: 45 percent / TEA; DMAP

3.1: 40 percent / NaHCO₃ / 80 °C

4.1: 83 percent / TEA / CH₂Cl₂ / 0 °C

With dmap; TEA; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; 1.1: Addition / 1.2: Reduction / 2.1: Tosylation / 3.1: Etherification / 4.1: Condensation;
DOI:10.1021/ja991300n