Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
CAS No.:124575-38-8
Molecular Formula:C₁₈H₂₄O₆
Molecular Weight:336.385
Hs Code.:

Synonyms:Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Suppliers and Price of Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

There total 2 articles about Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 124575-37-7
ethyl (4S,5S,2E)-6-benzoyloxy-4,5-isopropylidenedioxyhex-2-enoate

: 124575-38-8
Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)83439-6

Reference yield:

: 77332-99-1
(+)-(4R-trans)-5-<(benzoyloxy)methyl>-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde

: 124575-38-8
Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaH / 1,2-dimethoxy-ethane / 1.83 h / 0 °C

2: 79 percent / H₂ / Pd/C / ethanol / 2.5 h / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol;
DOI:10.1016/S0040-4020(01)83439-6

Reference yield:

: 124575-38-8
Benzoic acid (4S,5S)-5-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

: 124575-46-8,124602-07-9,124602-08-0,124602-09-1
(S)-1-Benzoyl-3-{3-[(4S,5S)-5-((3E,5E,7E)-3,7-dimethyl-nona-3,5,7-trienyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-propionyl}-5-isobutyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / Na / ethanol / 0.25 h

2: DMSO, oxalyl chloride, Et₃N / CH₂Cl₂ / 0.75 h / -78 °C

3: 72 percent / benzene / 16 h / Heating

4: 88 percent / H₂ / Pd/C / ethyl acetate

6: 97 percent / NaOH / ethanol; H₂O / 1.5 h / Ambient temperature

7: 92 percent / benzene; tetrahydrofuran / 18 h / Ambient temperature

8: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 8.5 h / -78 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1016/S0040-4020(01)83439-6