N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide)

Base Information

• Chemical Name: N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide)
• CAS No.: 161123-21-3
• Molecular Formula: C₂₄H₃₆N₄O₄S₂
• Molecular Weight: 508.706

Synonyms:N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide)

Chemical Property of N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide)

Chemical Property:

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Technology Process of N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide)

There total 2 articles about N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

piperazine (110-85-0) + N-(3-bromo-propyl)-4-methyl-benzenesulfonamide (3245-95-2) → N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide) (161123-21-3)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; for 24h; Reflux;

DOI:10.1016/j.ejmech.2016.10.043

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide) (161123-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate / ethanol / 24 h / Reflux

With sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2016.10.043

Reference yield: 61.0%

4,5-dichlorophthalonitrile (139152-08-2) + N,N'-(3,3'-(piperazine-1,4-diyl)bis(propane-3,1-diyl))bis(4-methylbenzenesulfonamide) (161123-21-3) → 1,12-bis[(4-methyl)sulfonyl]-1,2,3,4,6,7,9,10,11,12-decahydro-5,8-ethano-1,5,8,12-benzotetraazacyclotetradecine-14,15-dicarbonitrile (942923-87-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 96h;

DOI:10.1016/j.jorganchem.2007.02.013

upstream raw materials:

piperazine

N-(3-bromo-propyl)-4-methyl-benzenesulfonamide

p-toluenesulfonyl chloride

Downstream raw materials:

1,12-bis[(4-methyl)sulfonyl]-1,2,3,4,6,7,9,10,11,12-decahydro-5,8-ethano-1,5,8,12-benzotetraazacyclotetradecine-14,15-dicarbonitrile

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